Regulation of Fas (CD95)-induced apoptosis by nuclear factor- B and tumor necrosis factor- in macrophages
نویسندگان
چکیده
BIN LU,1 LIYING WANG,2 DJORDJE MEDAN,1 DAVID TOLEDO,1 CHUANSHU HUANG,3 FEI CHEN,2 XIANGLIN SHI,2 AND YON ROJANASAKUL1 1Department of Basic Pharmaceutical Sciences, Health Sciences Center, West Virginia University, Morgantown 26506; 2Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; and 3Nelson Institute of Environmental Medicine, New York University, Tuxedo, New York 10016
منابع مشابه
Tumor necrosis factor-alpha promotes macrophage-induced vascular smooth muscle cell apoptosis by direct and autocrine mechanisms.
OBJECTIVE We have previously shown that human macrophages induce human plaque vascular smooth muscle cell (VSMC) apoptosis by cell-cell proximity, Fas-L, and nitric oxide (NO), thereby predisposing to plaque rupture. This study sought to analyze whether tumor necrosis factor-alpha (TNF-alpha) contributes additionally to macrophage-induced VSMC apoptosis. METHODS AND RESULTS Macrophage-induced...
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